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Analysis of dispute settlement mechanism in Trade and Cooperation Agreement between the EU and the UK
Kurková, Michaela ; Šlosarčík, Ivo (advisor) ; Tomalová, Eliška (referee)
The thesis deals with the analysis of the dispute settlement mechanism in the Trade and Cooperation Agreement between the European Union and the United Kingdom of Great Britain and Northern Ireland. The present legal arrangements governing the relationship between the United Kingdom, as the first former member state, and the European Union entail a number of ambiguities in political and legal discourse. In order to obtain a comprehensive picture and achieve the research objective, the thesis also includes the Withdrawal Agreement and a selected new generation trade agreement, the EU-Korea Agreement, as part of its analysis. To achieve this objective, the thesis sets out to answer two research questions, that is (1) how the institutional provisions of the agreements involved in the system of dispute settlement differ from each other and, where applicable, from the provisions of standard trade agreements concluded by the EU, and (2) how the dispute settlement mechanism foreseen by the individual agreements differ from each other and, where applicable, from other dispute settlement mechanisms in EU trade agreements. By answering the research questions, the author tests the hypothesis of the persistence of EU influences on the dispute settlement system in the Trade and Cooperation Agreement and the...
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Molecular mechanisms of bacterial persistence to antibiotics
Jirsová, Anežka ; Lichá, Irena (advisor) ; Branny, Pavel (referee)
The ability to persist is inherent in the vast majority of bacterial species. Persisters represent a small heterogenous fraction of the bacterial population that can tolerate antibiotics. Unlike resistant cells, which are genetically distinct from the rest of the antibiotic-sensitive population, persister cells form a genetically indistinguishable subpopulation. Persisters arise either as a result of stress caused by adverse environmental conditions, or persister subpopulation arise as a result of stochastic induction independent of the presence of stressful conditions. There are various mechanisms by which bacterial cells have been shown to induce a persistent state. Toxin-antitoxin systems and their interaction with stringent response effectors play an important role during the development of persistence. The persistent state is also affected by changes in proton-motive force (PMF) and the fluctuations in the gene expression level of energy generating enzymes of the Krebs cycle (TCA). In this thesis, persister cells are characterized and the current knowledge about the molecular mechanisms leading to the induction of persistence in bacteria is summarized. Key words: bacteria, persistence, antibiotics, stringent response, PMF, TCA
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